My opinion (if you consider me knowledgeable and competent enough)
The main significance of top weight these days is being able to match it up with the appropriate pin distance in order to lay out the ball in such a way as to match up with the bowler and the condition. IE, its no good having high top weight and a 4-5 inch pin if you want a pin down rev leverage layout for a high speed. low rev player, conversely you dont want a high top weight 0-1" pin ball for a player who wants a pin out layout. It is probable in these situations that it won't be possible to layout the ball properly, even with a weight hole (at least not a legal one). This is where great care has to be taken to choose the correct pin/top weight combination for the player involved. This is where your coach/ball driller needs to have the knowledge and expertise to make the correct choices.
IN the case of mass bias balls, this is even more critical, given the mass bias component in the layout and its affect on ball reaction. If the top weight is too high in relation to the pin distance, then some layouts may not be possible, restricting the options in laying out the ball.